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Tools · Computational Biology

Antibody Numbering & Humanization

Number antibody, nanobody and TCR variable domains (IMGT, Kabat, Chothia), mark CDRs and assign the nearest human germline

Open in the appRun via API

Hardware and price

Price per run

What a typical run reserves from your wallet: the catalog's expected runtime on each piece of hardware × your plan's per-second rate. Larger inputs reserve more, and you're charged only for the seconds the job actually runs.

Antibody Numbering & Humanization: reservation per run, USD
HardwareTypical runtimeBasicStarterProEnterprise
CPUDefault3 min$0.025$0.014$0.009$0.0054

In workflows

Chain it with other steps.

Each input and output has a data kind, so the builder only connects steps that fit.

Inputs

  • Protein sequences (list) · optionalFASTA, RAW
  • Structures (list) · optionalPDB, CIF

Outputs

  • TableCSV
  • ArchiveZIP
  • Protein sequencesFASTA
  • TableCSV
  • Protein sequencesFASTA

References

The method behind it.

  1. James Dunbar, Charlotte M. Deane (2016). ANARCI: antigen receptor numbering and receptor classification. Bioinformatics. doi:10.1093/bioinformatics/btv552 (opens in a new tab)
  2. Marie-Paule Lefranc, Christelle Pommié, Manuel Ruiz et al. (2003). IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains. Developmental & Comparative Immunology. doi:10.1016/s0145-305x(02)00039-3 (opens in a new tab)
  3. Bissan Al-Lazikani, Arthur M. Lesk, Cyrus Chothia (1997). Standard conformations for the canonical structures of immunoglobulins. Journal of Molecular Biology. doi:10.1006/jmbi.1997.1354 (opens in a new tab)
  4. Tai Te Wu, Elvin A. Kabat (1970). An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity. The Journal of Experimental Medicine. doi:10.1084/jem.132.2.211 (opens in a new tab)

Run via API

Submit it from your own code.

Use an API key from your account. The estimate uses your plan's rates; submitting reserves that amount from your wallet.

# Estimate the reservation for your plan (payload fields: see the API reference)
curl -X POST https://api.cognichem.com/api/v1/jobs/estimate \
  -H "X-Api-Key: $COGNICHEM_API_KEY" \
  -H "Content-Type: application/json" \
  -d '{"job_type": "antibody-annotate", "resource": "cpu", "payload": {}}'

# Submit (retrying with the same Idempotency-Key never submits twice)
curl -X POST https://api.cognichem.com/api/v1/jobs/submit \
  -H "X-Api-Key: $COGNICHEM_API_KEY" \
  -H "Idempotency-Key: $(uuidgen)" \
  -H "Content-Type: application/json" \
  -d '{"job_name": "antibody-annotate-1", "job_type": "antibody-annotate", "resource": "cpu", "payload": { ... }}'
Payload fields and examples in the docs

Computational Biology

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